Achieve Your Desired Process
Ensure compound quality throughout scale up, while mitigating downstream and environmental risk in manufacturing. Our solutions include reaction optimization, analytical testing, and any relevant particle engineering, and Life-Cycle Assessment. Development and validation of test methods is routinely executed by our teams to meet your stability and quality-control testing requirements.
Initial Design of Experiments studies are performed on Cinthesis proprietary ball mill reactors. Conducted with speed and quality, we provide our clients with:
- Efficient use of reactants
- Minimal side reactions via milder conditions
- Simplified purification needs
- Unique, ownable process Intellectual Property
Located in the University of Cincinnati, Cinthesis has a full array of equipment and resources to meet your custom synthesis needs.
Cinthesis recognizes our clients typically require processes that can be commercially scaled up. We take the reaction conditions identified from our laboratory work in the ball mill, then scale up using twin-screw extrusion. This provides our clients with:
- Kilo quantities upon request
- Process operations and conditions which can easily be scaled to commercial production
- Support services to work on scale up
- Ability to work with our partners to produce larger or commercial runs.
We partner with our clients to establish the best way to analytically evaluate materials produced by Cinthesis’ mechanochemical processes.
Cinthesis has access to all the advanced analytical equipment at the University of Cincinnati, such as GC-MS, NMR, x-ray crystallography, etc. We partner with our clients to define requirements that best suit your particular needs.
For Pharmaceutical clients, Cinthesis will work with the University of Cincinnati, Department of Pharmacology to conduct pharmacokinetic studies of your materials produced via our process.
Mechanochemistry eliminates the need for reaction solvents, and has the potential for lower energy requirements due to milder conditions. Furthermore, due to higher selectivity and yields, less intensive purification is possible. Through our associates, Cinthesis can work with our clients to quantify the benefits of the recommended optimized mechanochemical process for your firm.