Welcome to the world of solventless synthesis.

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Benefits of Mechanochemistry

Mechanochemistry is nearing a tipping point. This once obscure discipline is becoming increasingly mainstream. There are many reasons for this:

  • Improved Kinetics
  • Milder & Safer Conditions & Reagents
  • Simpler, Cheaper Reaction Procedures
  • Higher Productivity
  • Decreased Process Mass Intensity

In total, mechanochemistry can deliver superior results compared to conventional methods.

Scaleable Chemistry

Anyone partnering with us to explore the transition from conventional, solution-based chemistry to mechanochemical, solvent-free conditions will learn how they can achieve all these benefits. Cinthesis is uniquely qualified to not only understand the fundamentals at the laboratory scale, but to also scale up to commercially viable solutions.

Our Machines


Modified Ball Mill

Cinthesis performs in-depth studies of reaction fundamentals via design of experiments to optimize reaction conditions, delivering the desired conversion, yield and selectivity for your specific needs. Work is done on the milligram to gram scale, allowing rapid iterations and learning.

Twin-Screw Extruder

Following optimization in the ball mill, Cinthesis can scale up your reactions utilizing a twin-screw extruder, producing materials on the kiloscale and providing the fundamental parameters for scale up to pilot, demo and commercial production.

The Mechanochemical Mindset


Energetics & Mixing

We design our systems such that reaction temperature can be robustly controlled. This enables control of mechanochemical reactions in entirely new ways.

Providing such an environment while also maintaining effective mixing can be a tricky balance. Striking a proper balance imparts significant rate enhancements, allowing better kinetics and selectivity under milder conditions. Our associates are experts at identifying the relevant parameters for this type of optimization.

Driving Forces & Unique Pathways

Just as the nature of a given solvent can control reactivity, so too can the absence of any solvent. For example, Pearson’s Hard-Soft, Acid-Base theory becomes even more important without solvent to break-up interactions between anions and cations.

Interestingly, this can be complemented and tweaked by incorporating catalytic or stoichiometric amounts of solvent which can also drastically change reaction outcomes and pathways.

In all cases avenues not possible in solution become available. Cinthesis can identify unique alternatives not possible through solution.

Translation & Execution

In addition to identifying unique reaction pathways, Cinthesis excels at translating a reaction developed under solvent-based conditions to mechanochemical ones. With our reactors and expertise, Cinthesis can readily translate classes of reactions including, but not limited to:

  • Suzuki, Sonogashira, and Buchwald couplings
  • Amide Couplings
  • Reductions & Oxidations
  • Bimolecular Nucleophilic Substitutions
  • Multi-Component Reactions

See Our Services

Cinthesis’ mission is to support your custom synthesis needs. We work with our partners to identify ownable unique intellectual property to deliver competitive advantage.